Is it a full moon or something?

I have to tell you there is something weird in the air around the SalTal household. It started a few days ago, our older kitty Izzy started getting more and more anti-social. Now this isn't too unusual for her, Izzy is a very low-maintenance kitty, she hangs out by herself and comes around when she wants attention or food and basically pals around with our other kitty Josie. However, she seems to be extra agitated lately, no one can get near her and she absolutely will not tolerate Josie within 5 feet of her. Andy and I have both picked her up and examined her to make sure she wasn't physically hurt somewhere and she doesn't seem to be sore anywhere, but we thought we would take her to the vet to be sure. Well, Andy couldn't even get her into the carrier this morning to go to said vet. She now is in her own private room (my office) quarantined in hopes that less stimulation will be good for her.

As if that wasn't worrisome enough, our Pepper pup will not go outside. She gets all scared and cowers down and we have to literally carry her outside and then she tries to run back into the house. This started last night. I have no idea what to think except that maybe there is some weird cosmic force at work that my very sensitive animals are picking up on and making them act funny.

Anyone have any experience with some sudden weird behavior in their animals? What did you do, if anything?